Reddit reviews Andy Pruitt's Complete Medical Guide for Cyclists

Don't know anything about this model of saddle, so I can't comment on its value in terms of "collectibles" or hand-crafted-ness or whatever.

I can say that this saddle embodies the opposite of current thinking as far as saddle shape is concerned. The trend today is to focus support on your Ischial Tuberosities (sit bones) and take it away from the soft tissue of your perineum. This saddle appears to put all the pressure on the perineum and take all the pressure away from your sit bones.

Probably wouldn't buy it if you put a lot of miles on the bike, as saddles of this shape have been proven to permanently compact blood vessels and reduce blood flow.

Source

Diagnosing knee pain is pretty tough because it's usually some combination of biomechanical flaws (of which there are many different points for adjustment as shown in /u/salzgablah 's good link) and strength, where weakness/unbalance in stabilizing muscles in the leg allow the knee/leg to not track properly.

People who are properly fitted can bike for a hundred plus miles in a day without significant knee discomfort.

I would recommend trying the suggestions in the chart and trying to get the fit right, but if you need a more comprehensive source, this book is pretty good: http://www.amazon.com/Pruitts-Complete-Medical-Guide-Cyclists/dp/1931382808

Andy Pruitt (http://www.amazon.com/Pruitts-Complete-Medical-Guide-Cyclists/dp/1931382808) says 25-35 deg, so Grantrules's recommendation is 100% accurate. 15% is almost straight and puts your saddle too high, and makes you at risk for IT band problems.

One way to do it is to just try different things. Different pedals, shoes, socks, cleat placement, seat height, etc.

Another is to find a really good bike fitter or a sports medicine doctor.

Either of those can get expensive. I recommend reading this book to learn the basics first.