Reddit reviews Footsteps of the Mountain Spirits.Appalachia: Myths, Legends, and Landscapes of the Southern Highlands

It seems like there are many historically significant things that have happened in Chattanooga through the centuries that may have drawn the attention of vampires looking to prey on the weak and helpless

https://en.wikipedia.org/wiki/Chattanooga,_Tennessee#History

https://www.smithsonianmag.com/smart-news/planned-public-sculpture-tennessee-honors-1906-innocent-lynching-victim-180968813/

or amass new bizarre powers, magics, or artifacts

http://mysteriousuniverse.org/2015/06/strange-mysteries-of-the-appalachian-mountains/

https://www.amazon.com/Footsteps-Mountain-Spirits-Appalachia-Landscapes-Highlands/dp/093280778X

http://forum.theonyxpath.com/forum/main-category/main-forum/the-new-world-of-darkness/vampire-the-requiem/178547-vampire-artifacts

or profit from the more modern realities of poor infrastructure

http://www.chattanoogan.com/2018/5/9/368475/Why-Are-The-Streets-Of-Chattanooga-In.aspx

http://nooga.com/216481/cornerstones-releases-annual-list-of-chattanooga-endangered-properties/

long 'supercommutes'

http://www.timesfreepress.com/news/local/story/2018/apr/29/chattanooga-super-commuters/469484/

and bizarre tastes

http://www.timesfreepress.com/news/local/story/2018/may/10/walmart-yodeler-masramsey-draws-massive-crowd/470447/

among a vulnerable human populace, where also notably (beyond moon pies being created) the entire fate of the world may rest with the nearby 'Oak Ridge' laboratory with roots in Chattanooga

https://allthingsnuclear.org/dlochbaum/made-in-chattanooga

developing Thorium salt reactors before the oceans of the planet return to a state of atoxia and kill all life on the planet

https://www.reuters.com/article/us-breakout-thorium-special-report-idINBRE9BJ0RH20131220

https://www.technologyreview.com/s/542526/china-details-next-gen-nuclear-reactor-program/

http://www.asiaone.com/china/2-chinese-nuclear-scientists-suspended-failing-stop-pseudo-scientific-taoist-ritual

https://phys.org/news/2018-04-oxygen-scientists-clues-recovery-mass.html

Although VTM is a separate game, here is an example of their efforts in Chattanooga which you also may find inspiring:

http://www.whitewolf.wikia.com/wiki/Rage_Across_Appalachia