Reddit reviews Life on the Edge: The Coming of Age of Quantum Biology
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I'm currently reading a book on this topic Life on the Edge that postulates quantum biology is the "magic factor" and we cannot currently make life as we do not grasp the understanding of how the quantum world can produce larger physical changes in the biological realm.
The idea of a simpler brain is a complex statement of itself. What do you define as small? What is simple or complex? If you had a neuron that fired when it was day time as it could detect light, is that a brain - or is that a machine?
Flys are often used in computational neuroscience as it is well understood and mapped, but it is still complex. Sadly I do not have a direct answer for you.
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