This looks great. One thing I'd recommend from a code perspective is to remove all the functions and store the mapping in a dictionary since your modifier is always the same. It should make it a bit more readable and maintainable if you ever want to move stuff around. I haven't done Python in a while so I'm guessing this won't work quite right, but something like:

Before installing ensure you have python and pip loaded

# Install evdev with 'sudo pip install evdev'<br />
# Install pyautogui with 'sudo pip install pyautogui'<br />
# Based on the concept at https://www.instructables.com/id/Wireless-UGS-Pendant/<br />
# and https://www.reddit.com/r/linux/comments/8geyru/diy_linux_macro_board/<br />
<br />
# Keypad used: https://smile.amazon.com/gp/product/B07TX57HR4/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&amp;amp;psc=1<br />
<br />
import os<br />
from evdev import InputDevice, categorize, ecodes<br />
import pyautogui <br />
<br />
# Event 5 is associated with the 10-key<br />
# Find this with 'cat /proc/bus/input/devices'<br />
dev = InputDevice('/dev/input/event5')<br />
# Grab the 10-key so it's input is only read by this program<br />
dev.grab()<br />
<br />
# Define actions<br />
# These keyboard shortcuts need to be enteres into your favorite<br />
# GCODE sender.  I use Universal GCODE Sender on my RPi<br />
# You can change these shortcuts to any other combination you like,<br />
# I found that the SHIFT-CTRL-ALT series was mostly unused<br />
mapping = {<br />
    # State<br />
    &quot;KEY_KP0&quot;: &quot;l&quot;, # unlock<br />
    &quot;KEY_ESC&quot;: &quot;i&quot;, # cancel       <br />
    &quot;KEY_TAB&quot;: &quot;o&quot;, # pause<br />
    &quot;KEY_EQUAL&quot;: &quot;p&quot;, # send program<br />
    &quot;KEY_DELETE&quot;: &quot;M&quot;, # connect<br />
<br />
    # XYZ<br />
    &quot;KEY_KP1&quot;: &quot;n&quot;, # home<br />
<br />
    # XY<br />
    &quot;KEY_KP2&quot;: &quot;h&quot;, # xy zero<br />
    &quot;KEY_KP9&quot;: &quot;1&quot;, # xymult10<br />
    &quot;KEY_KP7&quot;: &quot;2&quot;, # xydiv10<br />
<br />
    # X<br />
    &quot;KEY_KPSLASH&quot;: &quot;x&quot;, # reset x<br />
    &quot;KEY_KP4&quot;: &quot;a&quot;, # xjogneg<br />
    &quot;KEY_KP6&quot;: &quot;d&quot;, # xjogpos<br />
<br />
    # Y<br />
    &quot;KEY_KPASTERISK&quot;: &quot;c&quot;, # reset y<br />
    &quot;KEY_KP5&quot;: &quot;s&quot;, # yjogneg<br />
    &quot;KEY_KP8&quot;: &quot;w&quot;, # yjogpos<br />
    <br />
    # Z<br />
    &quot;KEY_KP3&quot;: &quot;z&quot;, # reset z<br />
    &quot;KEY_KPMINUS&quot;: &quot;r&quot;, # z jogneg<br />
    &quot;KEY_KPPLUS&quot;: &quot;f&quot;, # z jogpos<br />
    &quot;KEY_BACKSPACE&quot;: &quot;3&quot;, # z inc<br />
    &quot;KEY_KPENTER&quot;: &quot;4&quot;, # z dec<br />
    &quot;KEY_KPDOT&quot;: &quot;v&quot;, # probe z<br />
<br />
    # Feed<br />
    &quot;KEY_LEFT&quot;: &quot;6&quot;, # dec jog rate<br />
    &quot;KEY_RIGHT&quot;: &quot;5&quot;, # inc jog rate<br />
    &quot;KEY_DOWN&quot;: &quot;y&quot;, # feed reset<br />
    &quot;KEY_END&quot;: &quot;t&quot;, # feed dec<br />
    &quot;KEY_PAGEDOWN&quot;: &quot;u&quot;, # feed inc<br />
<br />
    # Unused<br />
    &quot;KEY_HOME&quot;: &quot;&quot;, # none<br />
    &quot;KEY_UP&quot;: &quot;&quot;, # none<br />
    &quot;KEY_PAGEUP&quot;: &quot;&quot;, # none<br />
    &quot;KEY_INSERT&quot;: &quot;&quot; # none<br />
}<br />
<br />
def send(key):<br />
    pyautogui.hotkey('ctrl', 'alt', 'shift', key)<br />
<br />
# Start reading input from the keyboard<br />
for event in dev.read_loop():<br />
    if event.type == ecodes.EV_KEY:<br />
    key = categorize(event)<br />
    # For troubleshooting, feel free to remove<br />
    print(key.keycode)<br />
    # If a key is pressed<br />
    if key.keystate == key.key_down:<br />
        # Set keyname to the keycode<br />
        # Could have used the numerical key nodes and a switch statement<br />
        # But this is more readable<br />
        keyname = key.keycode<br />
        character = mapping[keyname]<br />
        if character:<br />
            send(character)<br />
        else:<br />
            print(&quot;unknown command: &quot;, keyname)