Best vitamin b-complex supplements according to redditors

Hey mate, you're talking about what looks like pretty clear major depression. You're in good hands going to a psychologist (meaning this person has a PhD as opposed to an MA like a counselor, meaning they're more likely to know their shit -- and I say this as a contemptuous counselor regarding his profession), and a psychiatrist will put you on one of a few different antidepressants, like an SSRI or SNDRI. However, it's important to have a comprehensive medical ruleout for things like low testosterone, hypothyroidism, and nutrient deficiencies, like B12 and folate, both of which are hugely important for mood and energy. (Don't be surprised if your psychiatrist has no idea about these areas given how far behind doctors can be with the research -- 17 years on average.) If you know of any doctors who do functional or integrative medicine, this would be the place to look as well.

You might even consider ordering a fancier B-complex which includes methylated B12 and folate, like this. Also check out my post on the many non-psychological factors that influence depression. I highly recommend Stephen Ilardi's book, The Depression Cure, which goes into more detail about nonpharmacological treatments for depression, as well as Young and Klosko's Reinventing Your Life, which looks at psychological issues at a schema level, i.e., at a deep level of belief that can get activated at different times leading to different emotional and behavioral states. You can find the entire book here. Read the first five chapters and take the questionnaire in chapter two, then any schemas you rate highly on in the individual chapters by the same name.

It's actually an incredibly good read, but if you want a tl;dr, this is probably the easiest approach:

https://www.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0/

OK so my brain fog/memory issues mostly involved stuff like walking into a room and immediately forgetting why I walked in there, missing entire chunks of sentences when writing essays, forgetting a thought halfway through a sentence, a reduced vocabulary, and just general trouble retaining information. I read a study that suggested adding a folic acid supplement to lamotrigine monotherapy improved mood and memory outcomes, so I gave it a shot. I'm not totally back to normal, but I'm much, much better on the supplements than off the supplements. It took about 3 days for the FA to build up in my system and for me to notice the effects, and if I'm off the FA for ~3 days, I go right back to Brain Fog City. I use a complete B-complex supplement because it helps with other stuff but a solo FA supplement may work just as well. This is the supplement I use.

If that wasn't just a panic attack, it's probably because you took A LOT of methylB12 (5mg) and methyl folate (800 mcg).

I like the B-Right B-Complex from Jarrow. According to the nutrition label it has:

• 100mcg of methylB12, which is already 1,670% of DV
  
• 400mcg folate, which is 100% of DV
  
  Now, Daily Value isn't necessarily the threshold, but you took 50 times the amount of methylB12 as is in that supplement, which is 83,500% of your Daily Value.

jarrow, thorne, source naturals are all very good. NOW is decent. I try other brands on occasion based on amazon reviews and my own research of ingredients.

your vitamin c should be food-based, not ascorbic acid. good vitamin c isn't cheap, but it's worth it. ascorbic acid is nasty stuff.

I like https://smile.amazon.com/Synergy-Radiance-Wholefood-Vegetable-Company/dp/B008HFOLXW/ref=sr_1_3_a_it?ie=UTF8&qid=1499146191&sr=8-3&keywords=vitamin+c+food+based

and

https://smile.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0/ref=sr_1_1_a_it?ie=UTF8&qid=1499146227&sr=8-1&keywords=b+right

Just want to point out, that the ZMA supplement is very overpriced. If i understand correctly, it's 3 tablets each day, so it lasts 60 days for ~$23.

Here after a bit of searching on amazon i found:

Magnesium - $7 - 180 days

Zinc - $10 - 250 days

The B-6 should be also in the multivitamin, but if not, then:

B-Complex - $10 - 150 days - and it's even more B-vitamins and I would recommend taking B-Complex supplement.

So there you have it, for $27 you have supplements for at least 150 days VS 60 days on $23. Mind you I am not even from USA, so i guess you can find even better deals.

Hiiiiiiii.

I’ve been on 50,000IU/weekly + prenatal with Vitamin D since cycle 6; 500 mg of Vitamin C since cycle 7; and a B-complex since cycle 10. Here are my stats!

Cycles 10-12: 13 days • Cycle 9: 12 days • Cycle 8: 11 days* (NSAID cycle) • Cycle 7: 13 days • Cycles 1-6: 12 days.

Edit: 5DPO cramps are pretty common and don’t always mean your period is coming immediately. An LP that short would be something that would probably require a doctor’s intervention rather than OTC supplementation to address.

Your mileage may vary, but this is what worked for me:

1. Get a DNA test from 23andme
   
2. Download the CSV file from their website with your results and plug into livewello.com
   
3. See if you have the MTHFR gene mutation
   
4. If you do, start taking this: https://www.amazon.com/Thorne-Research-Complex-Vitamins-Capsules/dp/B00HST919C/ref=sr_1_11?crid=1S9CTXW72DVA9&keywords=mthfr%2Bb%2Bcomplex&qid=1565287604&s=gateway&sprefix=mthfr%2Bcomplex%2Caps%2C153&sr=8-11&th=1
   
   It took me years to figure out that my fatigue was being caused by my organism not being able to absorb Vitamin B because of the MTHFR gene. Once I figure this out, the fatigue was gone.
   
   On the other hand, if you don't have a defective MTHFR gene, these pills will do nothing for you, and it's likely the fatigue comes from somewhere else.
   
   Also if you do have MTHFR, DO NOT take folic acid supplements. Your body won't be able to break them down and it will accumulate over time.

Yep…

I use this particular combination of Jarrow supplements (some others not listed as well):

• Methyl Folate 1000 mcg
  https://www.amazon.com/Jarrow-Formulas-Methyl-Supports-Cardiovascular/dp/B015XYNSVK/
  Previously used Deplin (as prescribed). Jarrow is much cheaper as health insurance (in the US) doesn't cover "medical foods" /sigh.
  
  
• B-right Complex
  https://www.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0/
  Note this this formula includes 400mcg of Jarrow's Quatrefolic so it might be an option to consider compared to this one which /u/Entropy-Reigns mentioned.
  
  
• Vitamin D3 25 mcg (1000IU)
  https://www.amazon.com/dp/B073LMP2T2/
  
  FWIW, I had one doctor who tested directly for C677T but also did 23andMe (v2/v3) previously. Using http://geneticgenie.org and https://promethease.com to analyze the RAW data from 23andMe is one option for those looking to check without much fuss.
  
  Also worth noting 23andMe's blog post about MTHFR:
  https://blog.23andme.com/health-traits/our-take-on-the-mthfr-gene/

jarrow b-right is "low odor" and high quality https://www.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0

He did not recommend a specific brand, but told me to just focus on organic and natural rather than highly processed versions.

However, here is the link of what I use and this is the best in my opinion.

https://www.amazon.com/Garden-Life-Vitamin-Code-Capsules/dp/B00HFEE5DM/ref=sr_1_5_s_it?s=hpc&ie=UTF8&qid=1522466361&sr=1-5&keywords=garden+of+life+5000+iu

https://www.amazon.com/Garden-Life-Vitamin-Complex-Supplement/dp/B0098U0SQO/ref=pd_bxgy_121_img_2?_encoding=UTF8&pd_rd_i=B0098U0SQO&pd_rd_r=Q47WNTWBYPH3F2PGYCKB&pd_rd_w=HxeQ2&pd_rd_wg=FLfIQ&psc=1&refRID=Q47WNTWBYPH3F2PGYCKB


note: as some users said B vitamins are encouraged as well, so purchasing a B complex as my doctor said would cover them all.

Jarrow B-Right https://www.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0/ref=sr_1_1_a_it?ie=UTF8&qid=1466102146&sr=8-1&keywords=jarrow+b+right

Thorne Research

Thorne Research - Basic B Complex - B Vitamins in Their Active Forms - 60 Capsules https://www.amazon.com/dp/B00HST919C/ref=cm_sw_r_cp_api_i_jxZ3Cb5XYJNF9


Or

Thorne Research - B-Complex #12 - Vitamin B Complex With Active B12 and Folate - 60 Capsules https://www.amazon.com/dp/B0797JXKL9/ref=cm_sw_r_cp_api_i_OxZ3CbDB600E8

Or

Thorne Research - Methyl-Guard Plus - Methylation Support Supplement with 5-MTHF (Folate) and Vitamins B2, B6, and B12 - 90 Capsules https://www.amazon.com/dp/B00O5AHC4S/ref=cm_sw_r_cp_api_i_ZxZ3CbPTYVWK9

Look for ones listed with methylated B vitamins. This one I use...I think it’s good but there could be better ones out there.
bcomplex

Fucking lowlives. Sorry your mom got scammed. These are just general supplements that won't really do anything compared to a healthy diet. I wouldn't recommend buying them all. Maybe a multivitamin and fish oil, or a b-vitamin if she doesn't eat meat. Otherwise, they're likely a waste of money.

Here are some supplements I've taken that look like basically the same thing, though I don't see Amway's nutritional facts (with the list of ingredients) so I just have to go by the marketing nonsense on their site to guess at what all is in each.

Also, /r/supplements is great for questions like this.

1. just looks like a multivitamin
   
2. a superfood powder
   
3. cal-mag + d
   
4. fish oil
   
5. digestive enzyme
   
6. b vitamins
   
7. vitamin c complex
   
8. green tea
   
9. green tea with coenzyme q10. not sure about a supplement for that
   
10. probiotics
    
11. chondroitin, glucosamine, boswellia, and hyaluronic acid complex. you can find supplements and creams with these ingredients.

Or this one ... https://www.amazon.com/Life-Extension-Active-Complete-Complex/dp/B00DHTQNQ6/

I strongly prefer this as it uses reasonable doses and a high quality form of folate. Highest rated on Labdoor as well.

Jarrow's

http://amzn.com/B0016003Z0

Doctor's Best

http://amzn.com/B00DWDZPBG

Both active forms of Vitamin B 9 and 12

You know you can buy supplement methy B12 and folate ? I wouldn't inject anything I bought off the internet especially china.

Getting from a steroid website would be safer than China as those are peer reviewed on eroids.com

I'd stick with supplement methyl B complex rather than inject. Besides it isn't fat soluble so you'll only piss out anything your body doesn't use that day.

I have the MTHFR gene mutation so have issues with B12 so I take a methyl B complex and my sister has a deficiency despite taking regular b complex so I just got some for her too.

https://www.amazon.co.uk/gp/aw/d/B01787EPEE/ref=mp_s_a_1_2_a_it?ie=UTF8&qid=1521908644&sr=8-2&keywords=super+b-complex&dpPl=1&dpID=41QwRZ1vG2L&ref=plSrch

I personally experience best results when I take a food based B vitamin such as the ones that Garden of Life makes. The synthetic B complexes turn my pee dark yellow/green. (Link to the garden of life that I try and take as much as I can get it: https://www.amazon.com/Garden-Life-Vegan-Vitamin-Supplement/dp/B0098U0SQO/ref=sr_1_1?s=hpc&ie=UTF8&qid=1482954081&sr=1-1-spons&keywords=b+complex&psc=1)

As for the two that you linked, the first one has almost nothing in it. The RDAs for most vitamins are laughable, the fact that their doses barely exceed that means that it will probably do nothing for you.

Bronson Labs is an ok brand. I've taken their vitamin C from time to time. Now Foods, Viva Labs, Solgar, nature's way (note, not to be confused with the horrible brand, nature made) and Jarrow Foods are all decent brands as well. Anything from them that actually contains decent doses of B vitamins should be good. I would look into a B-100 complex too as those tend to contain more decent doses.

https://www.amazon.com/Thorne-Research-B-Complex-Vitamin-Capsules/dp/B0797JXKL9

> The established dietary cobalt requirements for ruminants are 0.1 to 0.2 mg per kg (0.05 to 0.09 mg per lb) of diet. Precise estimates of minimum cobalt requirements are difficult because of the influence of variables such as seasonal changes in herbage cobalt concentrations, selective grazing and soil properties. Under grazing conditions, lambs are the most sensitive to cobalt deficiency, followed by mature sheep, calves, goats and mature cattle (Andrews, 1956).

https://www.dsm.com/markets/anh/en_US/Compendium/ruminants/vitamin_B12.html

Here are some examples of B12 supplements for livestock:

https://www.drugs.com/vet/vitamin-b12-1000-mcg-injection.html

https://www.amazon.co.uk/VET-ONE-Vitamin-Complex-Potency/dp/B00FEI2N7G?SubscriptionId=AKIAILSHYYTFIVPWUY6Q&tag=duc08-21&linkCode=xm2&camp=2025&creative=165953&creativeASIN=B00FEI2N7G

Just go with Jarrow B-Right Works great for me.

I would drop the vinpocetine:

http://www.longecity.org/forum/topic/23457-vinpocetine-ditch-it/

Try taking the bacopa before bed, it makes some people tired.

Maybe lay off the CILTEP for a few days and try supplementing some glutamine, did wonders for me.

Try adjusting your choline intake, too much makes some people depressed, but not enough will also make you tired and brain foggy. Too much will give you muscle soreness and possibly a headache from muscle tension.

You could try some n-acetyl-tyrosine and see if it helps your motivation. I wouldn't take too much though since one of your ADs is a norepinephrine reuptake inhibitor. Have you always felt this unmotivated, or is it a recent phenomenon? If it's just a recent thing, what has changed in your life that might have caused it? If it is chronic, and n-acetyl-tyrosine works for you, you might want to ask your doctor about trying ritalin/methylphenidate.

I would also try to get off the SSRI/SNRI, serotonin is depressing. There is a common misconception, possibly due to incorrect ideas about how MDMA works, that serotonin makes you happy. SSRIs actually increase suicide risk for the first few weeks because the excess serotonin makes you depressed. The anti depressant effects take a few weeks because they are due to physiological changes in your brain due to the extra serotonin.

Do you take a multivitamin or any vitamins other than D? Personally I think the base of any nootropic stack should include a good multivitamin, some antioxidants, and probably fish oil, although some people react negatively to fish oil. Not including any racetams or ciltep or anything purely nootropic, every day I take:

AOR Ortho Core

B Complex

Vitamin C

Vitamin D-3

Vitamin E

Fish Oil

Green Tea Extract

Pine Bark Extract

Magnesium

Calcium

Probably less important, but I also take acetyl carnitine, alpha lipoic acid, alpha gpc, glucosamine/chondroitin/msm, rhodiola rosea, eluthero sibricus, jiaogulan, mushroom product including reishi and chaga, glutamine, l-phenylalanine, creatine, coq10, ashwagandha, lion's mane, bacopa, and astragalus.

In addition to all that I take various nootropics sort of randomly as I feel like, including sulbutiamine, piracetam, aniracetam, pramiracetam, noopept, and forskolin/artichoke/hesperidin.

Last, and probably most important, get plenty of good sleep.

Hi there, I sense your hair is thinning due to a vitamin deficiency. I sense you should take a good quality vitamin B supplement, like this one: https://www.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0/ref=sr_1_fkmr0_1_a_it?ie=UTF8&qid=1505639358&sr=8-1-fkmr0&keywords=vitamin%2Bb%2Bsuper%2Bcomplex%2Bjarrow&th=1

I also sense your body needs more calcium and vitamin D. As for the job you applied for, I sense that Ali has had a lot of applicants and is narrowing down the list as quickly as he can. It doesn't look like you've been disqualified, but he also hasn't completed the task of narrowing down the applicant list. I sense that you'll most likely hear back from him in 1.5 weeks or less.

I hope this helps, let me know if you have any questions :) Also, please share my link: http://clairvoyantreadingsforall.webnode.com/ thanks :-)

I was taking this one when the symptoms started:

Nature Made Super B Complex Tablets, 140 Count https://www.amazon.com/dp/B005D0DTS2/ref=cm_sw_r_cp_api_s6ioyb1WHQJQW

And since then, I have taken this one a few times and my symptoms get significantly worse. The most recent occasion was yesterday and the symptoms were the worst they've been since the first 3-4 days of them occurring:

Nature's Bounty Super B-complex with Folic Acid Plus Vitamin C, 150-Count https://www.amazon.com/dp/B0014D2GEK/ref=cm_sw_r_cp_api_P7ioybGRVP533

I'm not reading your post as rambling at all, actually, as it's quite specific to my interests! I also have been diagnosed with inattentive type ADHD which I've really struggled with, and symptoms I'd describe as similar to yours. Lack of motivation with a big side helping of anxiety, in my case. I wasn't able to tolerate any of the medications suggested by my P-doc, even Strattera which they give little kids. Reactions ranged from insomnia to personality changes to severe depression to, in one case a 103 degree fever! Go figure. I've had some luck with hemp oil, but sure wish I'd known I have essentially the worst case scenario for COMT mutations before I got onto the merry go round.

I don't want to get your hopes up, but I've been taking methylfolate for a couple of weeks now, a smallish dose still to be sure I could tolerate it (this is what I'm taking.) Yesterday I started supplementing with this SAM-e and.... the wire chewing feeling and dizziness (probably from hunger) went away and I feel really good! I'm noticing improvements in energy level and alertness, mostly. I'm afraid to get my own hopes up because I've had so many problems with medications generally but if this works without intolerable side effects it's going to be a life changer.

Drop me a PM or @ me here any time if you want to compare notes. I'm cutting the pills in half b/c I'm so sensitive to meds generally but hope to increase the dose before long. I'm taking 100 mg of SAM-e for now.

Update: Had to discontinue sam-E because I developed severe insomnia, and I suspect it made my PMDD worse. Also, vestibular migraines kicked up which may be a result of whatever was going on with my hormones. Will update in another month with whether I'm still having PMDD/migraine issues for any women who may try this stuff.

It depends on what the problem is, to be honest.

First you should see if you can find what I call a "sounding board." It's just someone who will let you scream and yell and rant or cry and be miserable but not offer advice/consolation unless you specifically ask for it. This is really cathartic, I don't know why.

Second, take a really hot shower and cry or scream. I'm not kidding, this is the most amazing release ever. From a brain chemistry/physiology perspective, what's happening is that all of your muscles are relaxing for the shower, then the screaming or crying (whatever you need to do) released endorphins, but EXTRA endorphins because all of your body is relaxed from the shower, and that gives you a really nice calm, sometimes happy afterglow type feeling. This is especially effective because when you have this calm/clear headed afterglow, you can find answers to your problems or finally release whatever is bothering you OR you can be in the right mindset to take steps towards solving your problems, both physical and mental steps forward :) It's a really incredible release. An alternative to shower is really hot bath, with the lights off. Just close your eyes, relax, and cry or scream or just lay there silently and let everything go...very nice.

I have lots of other things that help me out, if you're interested. Something that I've found works surprisingly well is just taking a complete "B" vitamin...it really fights off the "I don't want to get out of bed, I hate my life, I'm not going anywhere, I can't do anything, I just want to make up alternative realities in my head and stay in bed all day" mindset. [This] (http://www.amazon.com/Solgar-B-Complex-Vegetable-Capsules-Count/dp/B000RZQNV8/ref=sr_1_3?ie=UTF8&qid=1382111553&sr=8-3&keywords=b+complex+100) is the one that I use and it's pretty affective :) It DID make me really sleepy and lethargic for the first three or four days that I took it, but once my body got used to it, I was fine :)

This particular Country Life brand did this to me also for some reason. I've used other Country Life products with no problem.

A brand called Emerald "B Healthy", which is also Co-enzymted did not cause the drowsiness.

https://www.amazon.com/Healthy-Methyltetrahydrofolate-Coenzymated-Laboratories-Vegetable/dp/B004IP91RQ/ref=sr_1_2?crid=EOQYMMGDF3K0&keywords=emerald%2Bb%2Bhealthy&qid=1555809637&s=gateway&sprefix=emerald%2Bb%2Bh%2Cindustrial%2C157&sr=8-2&th=1

https://www.amazon.com/gp/product/B00DWDZPBG/

I have just found Doctor's Best products to be of good quality, so I went with what I know more or less. It certainly does give a nice little energy boost. It's subtle, but it's there.

Can't beat Jarrow B-Right

it can just don't overdo it. start with 400mcg methylfolate or less and don't go over 800mcg a day.

this is a really good b complex that isn't too excessive: https://www.amazon.com/gp/product/B00CFD0TC4/ref=oh_aui_detailpage_o01_s00?ie=UTF8&psc=1

I take this.
Other supplements you may want to look into that may aid in your situation (when you are in the position to expand your stack):

Rhodiola Rosea

Panax Ginseng

Acetyl L-Carnitine

Remember, step one should be adjusting your diet, exercise, and sleep!

That supplement would be fine.

It contains:

-methylated folate
-Pyridoxal phosphate(active form of b6)
And
-Methylcobalamin(b12)

You may be able to find them all separately for less money.

Or the Jarrow B complex is commonly reccomend, and contains the B vitamins in the same form. You'd have to compare dosages though.

Jarrow Formulas B-right Complex, Supports Engery, Brain and Cardiovascular Health, 100 Veggie Caps https://www.amazon.com/dp/B0016003Z0/ref=cm_sw_r_cp_apa_i_GMR6CbQP4QQ7W

This is what I take every day:

• Zinc
  
  
• Iron
  
  
• B-complex
  
  
• Hyperbiotics Probiotics
  
  
• Magnesium citrate
  
  
• Selenium (This is to lower my antibodies, which were nearly 600 at one point, and are down to under 150 now after several months on Selenium. I will stop taking selenium when the bottle runs out which I think will have been 6 months.)
  
  
• Omega fatty acids
  
  
• D3 5000iu
  
  As far as I know, based on the research that I did on these, this brand and these formulations are easiest to absorb.
  
  I also take 2.25 grain Nature Throid, at night, 4 hours after my dinner.
  
  In the past two weeks I've actually felt better than I have in years. I notice right away if I forget to take my vitamins or if I run out of one of them and miss just one of all those, it definitely is noticeable as well. I added magnesium in the past week and it has been incredibly encouraging how much more energy I've had on magnesium. But whatever you do, DO NOT get magnesium powder. It is absolutely disgusting. I'm usually able to choke down things if I know they're good for me, but magnesium powder is supposed to be mixed in liquid. Well... it clumps... and turns juice brownish green... and it tastes like poison... So ... get the caps lol
  
  I hope you get results soon.
  
  One thing I was thinking about with Hashi's is that absence of antibodies doesn't always mean no Hashi's. I mean, if my antibodies went all the way away due to treatment, that doesn't take away the diagnosis, and doesn't mean that I am "cured". It would just mean my Hashi's wasn't active.
  
  This doesn't mean that if your ultrasound comes back normal and your full thyroid panel comes back fine that you should act as though you do have Hashi's, just that, it can't be ruled out just because at the moment your antibodies were low. But I really think that the Celiac thing is worth thinking about. Despite medicating hypothyroidism, the vast majority of my pretty recent recovery came after removing gluten and soy from my diet.
  
  Good luck!

Ah yea. Not really max health, he was being facetious.

If you want to feel more alive in the mornings pop a vitamin B supplement with breakfast, it will make you more awake and feel better without the caffeine downside of energy drinks. I don't know if it will make you max health, but it allows me to do things in the first hour after waking up.

I know! I was a little sceptical but I really think it's due to the B-complex. I don't know for sure but I can't do any harm. After all the B vitamins help with the nervous system, right? I'm gonna buy it again and try to update.

This is the one, it's says take two tablets but I just take one: https://www.amazon.com/Super-B-Complex-Methylated-Vitamins-Methylcobalamin/dp/B01787EPEE/ref=sr_1_3_a_it?ie=UTF8&qid=1536008531&sr=8-3&keywords=igennus+super+b+complex&dpID=41j6dP0iqfL&preST=_SY300_QL70_&dpSrc=srch

Do you believe that the anabolic androgenic ratio rating (done in mice I know) could be a surrogate for non-AR mediated anabolism to AR mediated anabolism? You say that Test has equal effects through both mechanisms, which would be supported by this idea because it is 100:100.

Regarding androgen affinity of masteron you can see this full paper here.

You are correct that masteron has affinity for the androgen receptor, but interestingly it's androgenic rating is only 25-40, less than half that of testosterone. This could be suggestive that the majority of the effects are non-AR dependent. The hormone was originally intended for breast cancer patients, and I believe that it may mediate anabolic activity by acting as an antagonist at the estrogen receptor. By blocking receptor binding of estrogen, it may allow you to reap some of the anabolic effects (increased IGF-1, sodium retention) of estrogen without experiencing the femininization (sp?) properties.

Let me try to summarize the thoughts going around here, and see if I can suggest an option to address this.

1. High SHBG may be good for uncoupling anabolic effects from androgenic ones in AAS
   
2. AAS generally lower SHBG but have an overall anabolic effect
   
3. Estrogen production/aromatase activity results in SHBG production^1
   
4. Having androgen dominance in some tissues is good (tits, dick, brain [to a degree]) and bad in others (primarily hair).
   
5. Estrogenic dominance may be good for anabolism (probably good for mitigating hairloss) and one way may be through elevated SHBG
   
6. Estrogen mediated anabolism is likely most effective in insulin sensitive (low bodyfat) individuals
   
7. Insulin, GH, IGF-1, androgens, and prolactin negatively regulate SHBG production
   
8. So we see that the favorable anabolic products of estrogen reduce SHBG production. How then do we keep SHBG up, insulin sensitivity up, and favorable androgenic dominance in tissues where it matters.
   
   I am not sure I have the perfect answer, but here is how I plan to do it in my next cycle:
   
   
9. Keep DHT levels slightly above normal levels systemically via Testosterone E (600mg/wk) + finastride (1mg inhibits 64% of DHT at scalp) I expect this to give me about as much DHT as my cruise dose (Yes I know its high) of 210mg/wk at which I don't notice any major hairloss on. The reason I plan to use a high dose of testosterone is because I believe that in combination with finastride it uncouples the androgenic (DHT) from it's anabolic effects to a degree. Maybe if the mouse studies were done on mice receiving AI + Finastride + Testosterone the anabolic:androgenic ratio might be more like 100:35, giving it a relatively more favorable anabolic to androgenic ratio than boldenone. Also if you look at the binding profile of testosterone from the paper I linked, I believe that it may have antagonistic effects at the progestagenic receptor, and I believe I am sensitive to progestrone activity.
   
10. Keep Estrogen slightly elevated by using aromasin at sufficient doses to keep me slightly above range
    
11. Use an anti-androgen at the scalp (RU58841)
    
12. Use topical DHT cream at the nipple
    
13. Include masteron E (300mg/wk) for extra nipple protection
    
14. Include Bold Cyp (700mg/wk) because of it's relatively uncoupled anabolic to androgenic properties/ratio. Thought about using DHB instead, but in terms of it's grams/$ relative to bold cyp I am not sure the benefits of no 5-ar or aromatase activity would be worth it since boldenone already has very weak activity with aromatase and 5-ar. Additionally DHB and bold cyp share the same ratio, and despite bold cyp's reduced potency compared to DHB I could brew it at twice the concentration, so in the end I am pushing the same amount of oil.
    
15. Include metformin to attempt to maintain insulin sensitivity on a modest caloric surplus
    
16. Stick to /u/bznnnj 's recommended diet of 2:1 glucose to fructose ratio, high fiber, low fat (10-20%), appropriate protein (shooting for 1g/lb despite the common knowledge that only .85 is needed as I believe that improved nutrient partitioning and protein synthesis in enhanced users may necessitate increased protein, and even if that isn't the case the thermal effect of protein may improve my metabolism to keep the gains even leaner). This should hopefully keep that liver full and pumping insulin. Fat sources will be mainly animal derived (beef and eggs) with some almonds thrown in, veggies will be spinach and brocccoli (uncooked to maximize sulrophane content), fruits will be kiwis and oranges, carbs will be sweet potato (and basmati rice if this ends up being too much fiber [I currently tolerate around 50gs]). Thoughts behind this being that we want stable insulin and glucose and as such should stick to carb sources with low glycemic index/load and /u/bznnnj has already discussed the advantages of increased fructose. Animal fats are selected for fat soluble vitamins. Veggies, Fruits, and Starches are selected for good micronutrient ratios (high potassium low sodium) getting enough calcium iron and unsaturated fats etc.
    
17. I am staying away from anything that has affinity for the progesterone receptor as I am not sure how it plays into all the previously mentioned mechanisms, and I have had poor reactions to them in the past.
    
    I thought I would include supplement choices since I am writing a book here anyways:
    
    
18. nightime - melatonin , magnesium glycinate (2x docotors best), P5P (I have the MTHFR mutation so I take mainly active forms of B vitamins and usually above the RDA), Zinc, CoQ10, Garlic
    
19. Morning - 10K IU Vit D (I have a vitamin D receptor mutation so I again go above the RDA), Vit K, B-complex, 2 xFish Oil, uridine
    
20. In order to stabilize dopamine, because I believe I am susceptible to post-cycle depression due to increased dopamine sensitivity on cycle I: Don't partake in psychoactive substances on cycle (including coffee), and utilize the Mr. Happy Stack (crossovers from /r/nootropics will know this is Uridine + Fish oil + and Choline (get choline from my eggs)) and off cycle I use a mixture of microdosed and periodic full doses of LSD to improve my dopamine sensitivity (and to deepen spiritual connection), modafinil, and caffeine and L-theanine to help me with the androgenic comedown.
    
    I am on the fence about including HCG, because I was running it on a cruise for a while, but it was aggravating my pubertal gyno and when I went to get my bloodwork I found that I had above range prolactin and in range estrogen and test. I was only on AI + Test + 500IU HCG/wk administered E3D. I may include it just to improve lipid metabolism, and increase estrogenic tone, because boldenone seems to act similarly to masteron insofar as it has not well understood anti-androgen effects.
    
    Sorry for the manifesto.

I know exactly how you feel. "It sucks" doesn't even begin to describe it. There's nothing in my life that should make me upset but I can't be happy.
I got very lucky and found a new doctor that ran some genetic tests through True Health Diagnostics. Turns out I have a genetic mutation (MTHFR) that prevents folic acid passing my blood-brain barrier and creating all the substances responsible for happiness. I started taking an L-methyl folate supplement last week and feel like I'm waking up from a bad dream.
The genetic testing is expensive but you can pick up the supplement on amazon for twenty bucks. It may sound dumb but some B vitamins might actually do something for you. I'm not recommending this because you're unhappy, but because you're unhappy for no goddamn reason and you fucking should be. That's what made your story jump out to me.

I use this one. 2 tablets/day

I've been using this for over a year now and it has a mild calming effect due to the inositol in it.

Solgar – B-Complex “100” Vegetable Capsules, 100 Count – Promotes Energy Metabolism https://www.amazon.com/dp/B000RZQNV8/ref=cm_sw_r_cp_apa_i_UQF4Ab93TJWPQ

I'm not sure if it is only a B12 difficeincy, I was taking this . More like a generalized deficiencies of all sort. Which is quite normal knowing the poor state of our digestive tube. It is malabsorption, not a deficiency in the food we eat. Well B12 is kinda special actually it is made by bacteria, we actually produce it in enough quantities in our colon but we need to get to our stomach so we can absorb, the joy of the modern hygienic life :p

For B12 I believe it is absorption start in the stomach. So first question do you have ulcers? low stomach acid ? GERD is a good indicator of having low stomach acid, in that case protein bounded B12 won't help you that much, maybe tablets you can put under your tongue?

That's great! If it's working for you that's really good, and to be honest, buproprion is a lot scarier then a quarter dose of lithium. Just do some research on how lithium affects sodium, potassium, magnesium and the kidneys. You might need to be more diligent than average with making sure electrolytes stay balanced. Although at that dose, I'm talking more out of caution than worry. Genuinely though, congrats. Bupropion largely works on the cetecholamines dopamine and norepinephrine. I have noticed that people with a catecholamine issue often respond well to the coenzyme form of B vitamins, since they're needed almost through every step of neurotransmitter sysnthesis. They get depleted during stress, and are hard to replete one at a time from diet. Here is what I take. Any good product will have the same ingredients if you read the label.

https://www.amazon.com/gp/product/B01787EPEE/

8 hours of sleep and compound exercises like push-ups and pull-ups.

​

I would get this, better product.

https://www.amazon.co.uk/Country-Life-Coenzyme-Vegetarian-Capsules/dp/B0011FY9AU/ref=sr_1_3?keywords=b+complex+country+life&qid=1565290164&s=drugstore&sr=1-3

You can sometimes get b vitamin supplements that are just specific B vitamins. Like I have one that's just b12 that I take.

I also found this one that appears to not have folic acid in it. Unless I overlooked it.

ETA: I think people mostly take the B supplements for B6. So you should probably take B6 individually.

Whoops, I the link. Just added it above: https://www.amazon.com/gp/product/B00CFD0TC4/ref=oh_aui_detailpage_o02_s00?ie=UTF8&psc=1

I like this one:

https://www.amazon.com/gp/aw/d/B000GFPD2Y/ref=cm_cr_arp_mb_bdcrb_top?ie=UTF8

>Source Naturals coenzymated B complex

How does this compare to Vitamin Code's Raw B-Complex? Aside from the fact that VC uses more jingo-istic language.

Also, I'm guessing that you take Methylcobalamin more for the methyl component than the B12, since your B-Complex already has quite a lot of that.

You can get it at Whole Foods in the large bins. I use it sparingly on like salad and air-popped popcorn. But it's not the same as a potent b-complex by like Thorne or Pure Encapsulations.

(Much) cheaper option that I use - https://www.amazon.com/Life-Extension-Active-Complete-Complex/dp/B00DHTQNQ6/

B and D vitamins are ones that I've read can most affect brain fog. I've been taking Vitamin D for a couple years, enough so that my levels went from 10 (out of a minimum 100) to normal and was able to cut my dose back from 5,000 units to a 2,500 unit pill.

I've never tested officially low for B vitamins, but my first (good) doctor suspected a MTHFR gene mutation, which affects B vitamin absorption. I've been on a special folate for that for years, and added in B1 and B2 about 6 months ago which helped some. However, just this week I stumbled across a different B Multivitamin which is specially formulated for the MTHFR mutation, and includes folate along with the B vitamins. I've only been taking it for 3 days, but it seems to be helping as I've had noticeably more energy and have been sleeping better the past couple of days despite some seriously increased stress levels.

As another poster noted, magnesium is also helpful, in fact in addition to helping with muscle aches and sleep it can assist with Vitamin D absorption. I take magnesium citrate which is the most common form.

I am looking into https://www.amazon.com/Garden-Life-Vitamin-Complex-Supplement/dp/B0098U0SQO/ref=sr_1_2_sspa?s=hpc&ie=UTF8&qid=1511993775&sr=1-2-spons&keywords=vitamin%2Bcode%2Bb%2Bcomplex&th=1

Amazon link to Emerald Labs B Complex

This is what i've been taking for nearly 30 days now. i started it midway through cycle 10, and now in to cycle 11 my temps have really smoothed out. My charts used to look like the Rockies and now it's more text-book looking.

http://imgur.com/GbcCTi5 (Total list of things you can do)

You need to regulate your hormones. By the way, people here will always just blame it on the hormones. But remember, your hormones will get out of whack for a reason, there are precursors that caused something to happen.

This isn't caused solely by puberty. It's a mixture of characteristics. Here's what you can do for a cheap remedy that you can get in Europe.

-Eliminate refined sugars from your diet. Refined sugars bring no benefit and only bring harm to your body.

-Adequate vitamin D. You can get vitamin D for free just by getting out in the sun and getting exposed.

-Exercise everyday. If you have access to a Sauna, go there after you exercise. Make sure you wash your face after you exercise.

-Sleep 8 hours a day. Change your pillowcases every other day.

Supplements that are game changers:
OptiZinc - Take 100mg of Zinc a day.

Boron - Take 6 mg of Boron a day.

B-complex - Once a day

Vitamin D with K2 - Take 2000 IU of Vitamin D a day w/ K2. Also take fish oil and a multivitamin, if you can afford one.

Those right there will change your acne. Limit dairy consumption as well. That should cure your acne or make it very controllable. If you can, go to a dermatologist and try to get a retinoid cream.

Yup - I have pre-diabetic levels and am debating if I should go on metformin early or not. PCP/endos don't recommend it. Chris Masterjohn even said that he thinks it's too major of a pathway to interrupt for that long of a time. Others like Peter Attia, however, are all about it.

I'm a bit torn, but given my known condition and genetics, it might be a good gamble for me.

BTW, masterjohn recommended these B vitamins as the only ones he likes:

https://www.amazon.com/Source-Naturals-Coenzymate-Complex-Tablets/dp/B000GFPD2Y/

-_- can't tell if srs...Amazon brah!

Try Life Extension then. $8 for a month.

https://www.amazon.com/Life-Extension-Bio-Active-B-Complex-Vegetarian/dp/B00DHTQNQ6

https://www.amazon.com/dp/B00FEI2N7G/ref=cm_sw_r_cp_awdb_EaLNzbXDGCP7W

Vet grade B Complex.

Doctor's Best multivitamin

It has the best form of everything (no synthetics) at a reasonable price, but you might need to limit methyl b12's depending on your VDR taq status. Check this out for more: http://methyl-nation.com/comt-vdr-taq-the-mutation-series/.

Taking one of these multis a day (says to take 3) hasn't given me any overmethylating symptoms so far. Each capsule has way more of everything compared to your average multi, so 1 should be good to shore up an otherwise healthy diet avoiding folic acid wherever you can.

Here's another idea I've been toying with and might try myself, in case you can't tolerate any methyl b12: make your own "multi" stack with minerals and a b complex, adding L-methylfolate (only need half of these) and hydroxy/adenenosyl b12 seperately if you want those. This leaves A/C/D/E/K which I believe can be pretty much covered in a healthy diet and supplemented cheaply (D+C). If you have GSTP1 mutation, you should be avoiding supplemental E.

That B complex has the best forms of the other B's and leaves out Folic Acid and B12 for us. There's another, cheaper brand on amazon without Folic Acid but it has cyano b12. I'm not sure why cyano b12 is so bad to be honest - everything I read on the net about it is kind of vague/woo-woo, but I'm erring on the side of caution anyway (at a cost to the wallet!). Perhaps you can enlighten me?

Hope this was helpful, good luck.

edit: found this on knowyourgenetics.com

>Cyano B12 contains a cyanide molecule. So when you take cyano B12 your body must first turn
it into hydroxy B12 in order to use it, and then must find a way to get rid of the toxic cyanide
molecule. We all know cyanide is a poison even if the rest of the B12 molecule is good for you.
The body actually uses hydroxy B12 in order to detoxify cyanide. So, not only is cyano B12 not
the form your body ultimately needs, but taking higher doses of cyano B12 may actually deplete
your hydroxy B12. So why would anyone use cyano B12 if it can be toxic? Well, in low doses it
may be helpful for the eyes, but for the most part cyano B12 is used because it is much less
expensive, and a form of B12 that is easier to keep stable.

Alright so honestly it sounds like as long as you get hydroxy, a little bit of cyano isn't a big deal (cyanide fears are majorly overblown reportedly). With that said I'm going to probably go with this B complex that's a much better value & low in cyano b12.

1 pill a day, and 180 per bottle ($25)- https://www.amazon.com/Keto-Electrolyte-Hydrating-Replacement-Supplement/dp/B079QCNHLG

Or:

100 tablets ($6) https://www.amazon.com/Nature-Made-Potassium-Gluconate-tablets/dp/B00EYC4D62/ref=sr_1_5_s_it?s=hpc&ie=UTF8&qid=1540316830&sr=1-5&keywords=potassium%2Bsupplement&th=1

200 Tablets ($8) https://www.amazon.com/Natures-Bounty-Magnesium-Supplement-Vegetarian/dp/B00H5PJ0HW/ref=sr_1_5_s_it?s=hpc&ie=UTF8&qid=1540316731&sr=1-5&keywords=magnesium%2Bsupplement&th=1

150 Tablets ($8) https://www.amazon.com/Natures-Bounty-Complex-Vitamin-Tablets/dp/B0014D2GEK/ref=sr_1_8_a_it?ie=UTF8&qid=1540316809&sr=8-8&keywords=b%2Bvitamin%2Bsupplements&th=1&psc=1

So, $25 for simplicity, or $22 to take 3 a day.

The question "what has had the most significant effect for you?" has been posed in /r/nootropics and /r/stackadvice before. The #1 answer is always exercise. Exercise will have a much more significant effect than any nootropic, and the recommendation is always to ensure that sleep, diet, and exercise are all taken care of before experimenting with nootropics.

That being said, some supplements can definitely help to address anxiety/depression. Let me also say that every body is different; and between two people who are trying to ameliorate the same condition, the same supplement could help one and worsen the other.

The essentials for anyone are: Omega-3s, magnesium glycinate, and a B-complex. Also consider ALCAR and a choline source (such as alpha-GPC).

Supplements that people report being beneficial for anxiety/depression (and therefore focus, energy, mental capacity): ashwagandha, rosea rhiodola, L-theanine bacopa, SEMAX, memantine.

There are plenty (1, 2, 3) of reports on what has worked for certain people to tackle their anxiety/depression. (Click through all of those).

My recommendation for you would be to get this magnesium, some good fish oil, and this B-complex. Then give SEMAX a shot. Then maybe look into bacopa, aswagandha, etc.

Regarding noopept: "Noopept reduces anxiety and depression for me. When I went through a bad time it would immediately take the emotion out of me." Perhaps try it too.

Our current stack looks like this and is still a work in progress. Please comment as to what might be better options, thanks!.

Updated 8/30:

Protein Smoothie - Garden of Life, 1x/day in am
https://www.amazon.com/Garden-Life-Organic-Vitamins-Probiotics/dp/B007SYT7LO/ref=sr_1_4_s_it?s=hpc&ie=UTF8&qid=1503340441&sr=1-4&keywords=garden%2Bof%2Blife%2Bprotein%2Bpowder&th=1#customerReviews

Green Drink - Garden of Life, 1x/day in am w/ prot smoothie
https://www.amazon.com/Garden-Life-Vegan-Superfood-Powder/dp/B00FB1S988/ref=sr_1_2?s=hpc&ie=UTF8&qid=1503340620&sr=1-2-spons&keywords=garden+of+life+green+superfood+powder&psc=1

Multi - Centrum Silver then changing to Pure Encapsulations, 1xday in am w/ breakfast
https://www.amazon.com/Pure-Encapsulations-Multivitamin-Essentials-Hypoallergenic/dp/B00CBYG1L0/ref=sr_1_4_a_it?ie=UTF8&qid=1503339918&sr=8-4&keywords=pure+encapsulations+multivitamin

Lecithin (phos choline) - Moms Organic Market sunflower<br /> no link<br /> <br /> Fish Oil - Nordic Naturals, 2x/day in am/pm<br /> https://www.amazon.com/Nordic-Naturals-ProOmega-2000-Lemon/dp/B017UTEA4K/ref=sr_1_30_s_it?s=hpc&amp;amp;ie=UTF8&amp;amp;qid=1503340380&amp;amp;sr=1-30&amp;amp;keywords=nordic+naturals+fish+oil<br /> <br /> B12 - Jarrow Forumla Methyl, 1x/day in am<br /> https://www.amazon.com/gp/product/B00VE9B9II/ref=ox_sc_act_title_1?smid=ATVPDKIKX0DER&amp;amp;th=1<br /> <br /> Ginko - Moms Organic Market, 2x/day in am/pm
no link

L-theanine/Gaba - Allergy Research Group, 2x/day in am/pm
https://www.amazon.com/Allergy-Research-Group-Vegetarian-Capsules/dp/B000GU4TXI/ref=sr_1_5_s_it?s=hpc&ie=UTF8&qid=1503340983&sr=1-5&keywords=allergy+research+group

Melatonin - Moms Organic Market, 1x/day in pm<br /> no link<br /> <br /> Digestive Support - Trifal Ayush Herbs, 1x/day in pm<br /> https://www.amazon.com/Ayush-Herbs-Herbal-Supplement-Trifal/dp/B0012ZY6VG/ref=sr_1_11_s_it?s=hpc&amp;amp;ie=UTF8&amp;amp;qid=1503341173&amp;amp;sr=1-11&amp;amp;keywords=ayush+herbs<br /> <br /> Magnesium - Mega Mag Moms Market, 1x/day in pm
no link

Aloe Vera - Solaray, 1x/day in pm - plan to discontinue when done
https://www.amazon.com/Solaray-Aloe-Vera-Gel-capsules/dp/B00014FGHW/ref=sr_1_1?s=hpc&ie=UTF8&qid=1503341317&sr=1-1-spons&keywords=solaray+aloe+vera&psc=1

Vitamin C - Viva Naturals, 2x day in am/pm
https://www.amazon.com/gp/product/B00C6C3GCY/ref=od_aui_detailpages00?ie=UTF8&psc=1

DHEA - Zhou, 1x day in am
https://www.amazon.com/gp/product/B00UXLUFJ2/ref=od_aui_detailpages00?ie=UTF8&psc=1

Phos Serine - Doctors Best, 2x day in am/pm<br /> https://www.amazon.com/gp/product/B0036FWOJQ/ref=od_aui_detailpages00?ie=UTF8&amp;amp;th=1<br /> <br /> Alcarn - Natures Trove, 2x day in am/pm
https://www.amazon.com/gp/product/B01NCOTSWG/ref=od_aui_detailpages00?ie=UTF8&psc=1

CoQ10- Garden of Life Raw, 1x day in am
https://www.amazon.com/gp/product/B005JAT54S/ref=od_aui_detailpages00?ie=UTF8&psc=1

B Complex - Garden of Life Raw, 2xday in am/pm
https://www.amazon.com/gp/product/B0098U0SQO/ref=od_aui_detailpages00?ie=UTF8&psc=1

Current on order:

Turmeric/Curcumin - Key Nutrition
https://www.amazon.com/gp/product/B01LWA6WO8/ref=ox_sc_act_title_1?smid=A1ILK2NFE4Q1Q1&th=1

PQQ - Health Through Nutrition
https://www.amazon.com/gp/product/B00SA2JLBY/ref=ox_sc_act_title_2?smid=AP6P3N856MFIS&th=1

Resveratrol - BRI Nutrition
https://www.amazon.com/gp/product/B00LPW9X32/ref=ox_sc_act_title_3?smid=A196A8GC0YNHR&psc=1

Alpha GPC - VitaMonk
https://www.amazon.com/gp/product/B01K13ACDA/ref=ox_sc_act_title_4?smid=A3PSSFJH9JG29L&psc=1

Alpha-Lipoic Acid - Doctor`s Best
https://www.amazon.com/gp/product/B004O672ES/ref=ox_sc_act_title_5?smid=ATVPDKIKX0DER&th=1

Bacopa Monnieri - Pure Mountain Botanicals
https://www.amazon.com/gp/product/B00S02A1UO/ref=od_aui_detailpages00?ie=UTF8&psc=1

Ashwagandha - Nutra Herbs
https://www.amazon.com/gp/product/B01GZALWGO/ref=od_aui_detailpages00?ie=UTF8&th=1

Bacopa will be replacing Ginko and Alpha GPC will replace the lecithin. Any other suggestions are welcome, the stack in its current form is a bit unmanageable however it helps to empty the capsules into the protein smoothie in the morning and into a blueberry keifr milk smoothie in the afternoon or early evening.

Have you looked at Jarrow B Right?

https://www.amazon.com/Jarrow-Formulas-B-right-Supports-Cardiovascular/dp/B0016003Z0/ref=sr_1_1_a_it?ie=UTF8&qid=1495423387&sr=8-1&keywords=B+Right+vitamins

B vitamins? They're crazy cheap. Less than 9 cents a day at Walgreens, an entire year's worth for $14 on amazon. Prefer gummies? 5 cents a day.

I bought this supplement:

http://www.amazon.com/Jarrow-Formulas-B-right-Complex-Veggie/dp/B0016003Z0/ref=cm_cr_dp_asin_lnk

and I decided to take it once a day. SAMe is expensive, so I'm just gonna take 1 of these "b right" pills and 600 mg NAC 2x a day and see how that helps. The B right only has 100mcg of B12 though, should I look to up the B12 significantly?

Removed my other link because it was from Australia

https://www.amazon.com/Vitamin-Complex-Potency-Cattle-Swine/dp/B00FEI2N7G

Why does this product exist if animals aren't given b12?