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Do you believe that the anabolic androgenic ratio rating (done in mice I know) could be a surrogate for non-AR mediated anabolism to AR mediated anabolism? You say that Test has equal effects through both mechanisms, which would be supported by this idea because it is 100:100.

Regarding androgen affinity of masteron you can see this full paper here.

You are correct that masteron has affinity for the androgen receptor, but interestingly it's androgenic rating is only 25-40, less than half that of testosterone. This could be suggestive that the majority of the effects are non-AR dependent. The hormone was originally intended for breast cancer patients, and I believe that it may mediate anabolic activity by acting as an antagonist at the estrogen receptor. By blocking receptor binding of estrogen, it may allow you to reap some of the anabolic effects (increased IGF-1, sodium retention) of estrogen without experiencing the femininization (sp?) properties.

Let me try to summarize the thoughts going around here, and see if I can suggest an option to address this.

1. High SHBG may be good for uncoupling anabolic effects from androgenic ones in AAS
   
2. AAS generally lower SHBG but have an overall anabolic effect
   
3. Estrogen production/aromatase activity results in SHBG production^1
   
4. Having androgen dominance in some tissues is good (tits, dick, brain [to a degree]) and bad in others (primarily hair).
   
5. Estrogenic dominance may be good for anabolism (probably good for mitigating hairloss) and one way may be through elevated SHBG
   
6. Estrogen mediated anabolism is likely most effective in insulin sensitive (low bodyfat) individuals
   
7. Insulin, GH, IGF-1, androgens, and prolactin negatively regulate SHBG production
   
8. So we see that the favorable anabolic products of estrogen reduce SHBG production. How then do we keep SHBG up, insulin sensitivity up, and favorable androgenic dominance in tissues where it matters.
   
   I am not sure I have the perfect answer, but here is how I plan to do it in my next cycle:
   
   
9. Keep DHT levels slightly above normal levels systemically via Testosterone E (600mg/wk) + finastride (1mg inhibits 64% of DHT at scalp) I expect this to give me about as much DHT as my cruise dose (Yes I know its high) of 210mg/wk at which I don't notice any major hairloss on. The reason I plan to use a high dose of testosterone is because I believe that in combination with finastride it uncouples the androgenic (DHT) from it's anabolic effects to a degree. Maybe if the mouse studies were done on mice receiving AI + Finastride + Testosterone the anabolic:androgenic ratio might be more like 100:35, giving it a relatively more favorable anabolic to androgenic ratio than boldenone. Also if you look at the binding profile of testosterone from the paper I linked, I believe that it may have antagonistic effects at the progestagenic receptor, and I believe I am sensitive to progestrone activity.
   
10. Keep Estrogen slightly elevated by using aromasin at sufficient doses to keep me slightly above range
    
11. Use an anti-androgen at the scalp (RU58841)
    
12. Use topical DHT cream at the nipple
    
13. Include masteron E (300mg/wk) for extra nipple protection
    
14. Include Bold Cyp (700mg/wk) because of it's relatively uncoupled anabolic to androgenic properties/ratio. Thought about using DHB instead, but in terms of it's grams/$ relative to bold cyp I am not sure the benefits of no 5-ar or aromatase activity would be worth it since boldenone already has very weak activity with aromatase and 5-ar. Additionally DHB and bold cyp share the same ratio, and despite bold cyp's reduced potency compared to DHB I could brew it at twice the concentration, so in the end I am pushing the same amount of oil.
    
15. Include metformin to attempt to maintain insulin sensitivity on a modest caloric surplus
    
16. Stick to /u/bznnnj 's recommended diet of 2:1 glucose to fructose ratio, high fiber, low fat (10-20%), appropriate protein (shooting for 1g/lb despite the common knowledge that only .85 is needed as I believe that improved nutrient partitioning and protein synthesis in enhanced users may necessitate increased protein, and even if that isn't the case the thermal effect of protein may improve my metabolism to keep the gains even leaner). This should hopefully keep that liver full and pumping insulin. Fat sources will be mainly animal derived (beef and eggs) with some almonds thrown in, veggies will be spinach and brocccoli (uncooked to maximize sulrophane content), fruits will be kiwis and oranges, carbs will be sweet potato (and basmati rice if this ends up being too much fiber [I currently tolerate around 50gs]). Thoughts behind this being that we want stable insulin and glucose and as such should stick to carb sources with low glycemic index/load and /u/bznnnj has already discussed the advantages of increased fructose. Animal fats are selected for fat soluble vitamins. Veggies, Fruits, and Starches are selected for good micronutrient ratios (high potassium low sodium) getting enough calcium iron and unsaturated fats etc.
    
17. I am staying away from anything that has affinity for the progesterone receptor as I am not sure how it plays into all the previously mentioned mechanisms, and I have had poor reactions to them in the past.
    
    I thought I would include supplement choices since I am writing a book here anyways:
    
    
18. nightime - melatonin , magnesium glycinate (2x docotors best), P5P (I have the MTHFR mutation so I take mainly active forms of B vitamins and usually above the RDA), Zinc, CoQ10, Garlic
    
19. Morning - 10K IU Vit D (I have a vitamin D receptor mutation so I again go above the RDA), Vit K, B-complex, 2 xFish Oil, uridine
    
20. In order to stabilize dopamine, because I believe I am susceptible to post-cycle depression due to increased dopamine sensitivity on cycle I: Don't partake in psychoactive substances on cycle (including coffee), and utilize the Mr. Happy Stack (crossovers from /r/nootropics will know this is Uridine + Fish oil + and Choline (get choline from my eggs)) and off cycle I use a mixture of microdosed and periodic full doses of LSD to improve my dopamine sensitivity (and to deepen spiritual connection), modafinil, and caffeine and L-theanine to help me with the androgenic comedown.
    
    I am on the fence about including HCG, because I was running it on a cruise for a while, but it was aggravating my pubertal gyno and when I went to get my bloodwork I found that I had above range prolactin and in range estrogen and test. I was only on AI + Test + 500IU HCG/wk administered E3D. I may include it just to improve lipid metabolism, and increase estrogenic tone, because boldenone seems to act similarly to masteron insofar as it has not well understood anti-androgen effects.
    
    Sorry for the manifesto.

I'll give you some instructions directly! Firstly, I use these trays and buy my seeds here.


The most important factors I've found are proper disinfection of equipment and draining all the water. Really can't emphasize these points enough. With that in mind....

1. Soak the seeds for 2 hours in a jar that's been sanitized with bleach and hot water
   
   
2. Always clean your trays with bleach and hot water and store/grow in places where it won't be susceptible to air born infection (I used to leave the trays close to the stove and bacon particulates would get in and cause problems. Don't do that).
   
   
3. When the soak is done, spread the seeds evenly between the trays. It's really important that you don't have too many seeds per tray or it will congest drainage. Less is more!
   
   
4. Make sure ALL the water is drained out of the trays. You may need to run your washed fingers along the bottom edge of the trays to break water tension and allow full drainage.
   
   
5. Twice a day, rinse the sprouts under cold water and drain ALL the water before restacking the trays.
   
   
   Any warnings in there are due to negative experiences I've had. Please heed them carefully. Hope that helps!
   
   
   Edit: One more thing, don't let the seeds germinate too long. The longer you leave them, the greater the chance of infection. 3-4 days is all it takes.

This guy is the full package and has more understanding in this space than the cardiologist I work with who NEVER prescribe any form of vitamin K and in fact only think about it in terms of K1 and it’s effects on Coumadin.

K2-7 were nutrients found in fermented foods and raw diary. Now Those things don’t exist in any reasonable amount in today’s grocery store/USDA model of a food system.

I have taken one of these twice a day for years since 2013. /u/I will be switching to this starting this month.

This year I had a cardiac cath and cardiac MRI as well as the obvious ECHO for that matter. Nothing, despite my fluctuations in weight, years of high CRPhs and homocysteine. They even performed intra-artery ultra sound and came up with nothing still.

Despite my hyper insulinemia my A1c is 4.2-5.2 depending on the diet and if metformin is being used at the time. I also have youth on my side as I’m an 80s child.

My cardiologist was astounded and said I can’t put zero CAD but I couldn’t find any so I put <15%. I think I owe a lot to nutrient timing and k2 supplements.