Reddit reviews Lehninger Principles of Biochemistry

Since you didn't say what exactly you wanted a source for, and just told me to shut up, I'm not sure what exactly you want me to provide. There are a lot of physiology and biochemistry texts to which I can refer you if you'd like to read up on fructose, insulin, and leptin, as these are basic physiological principles. Boron and Boulpaep's Medical Physiology and Lehninger's Principles of Biochemistry are good ones. The nutrition information is also pretty basic. Here's a list of the fructose content of fruits and here's an article from the American Journal of Nutrition discussing the different forms of HFCS, its chemistry, and some of the science around it.

As for the chemistry of fructose as it relates to HFCS, here is a good article from the journal Nutrition and Metabolism, Fructose metabolism in humans – what isotopic tracer studies tell us, that gives a really nice overview of the physiology and biochemistry of fructose. It also does a review of the literature surrounding the purported role that HFCS plays in the obesity problem in the western world. However, one might be inclined to dismiss the article, as it is written by scientists employed by ADM. It's fair to raise this as a possible conflict of interest for the review part of the article. The first part, though, that discusses fructose metabolism, is "morally neutral" -- it doesn't say anything good or bad about fructose, just what happens to it and what they learned from tracer studies.

Given that one could question the review part of the previous article, here are a few other recent articles about fructose and HFCS:

A meta-analysis from 2014 that found no link between increased consumption of sugar of any kind and non-alcoholic liver disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135494/

A double-blind study from 2015 that interestingly found that ingestion of fructose or sucrose-sweetened beverages led to increased food consumption, but that ingestion of aspartame-sweetened beverages did not lead to excess food consumption: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658464/

The title of this randomized, double blind study from 2016 speaks for itself: Fructose Containing Sugars at Normal Levels of Consumption Do Not Effect Adversely Components of the Metabolic Syndrome and Risk Factors for Cardiovascular Disease

To be fair, there are a lot of articles on PubMed that say things like, "HFCS linked to arthritis/bronchitis/CVD/etc." The reason I didn't link those was not because they didn't suit my narrative -- notice I did link a study that found that people who consumed HFCS and sucrose-sweetened beverages ate more food. No, the reason I didn't link them was because I didn't think they were good studies because they couldn't establish HFCS as the causative factor. Was it the fructose, or just sugar in general? Or was it obesity? Conditions associated with obesity? There were too many confounders for which the studies didn't control, and they need to be repeated with better controls before they can be taken seriously.

Shall I give more links? Or am I to "shut up now?"

> Lets look at the source on the website. "From Lehningher principles of Biochemistry..." Originally published: 1970. So a source 47 years old. That makes sense, no chance science has advanced one iota in half a fucking century.

The seventh addition was published in 2017. What made you think I was referencing the 1970 edition? Oh, you're a biased Darwinist.


https://www.amazon.com/Lehninger-Principles-Biochemistry-David-Nelson/dp/1464126119

Read it an weep.

>Haloferax volcanii, a Prokaryotic Species that Does Not Use the Shine Dalgarno Mechanism for Translation Initiation at 5′-UTRs Published: April 14, 2014

>A translational enhancer derived from tobacco mosaic virus is functionally equivalent to a Shine-Dalgarno sequence. Proc Natl Acad Sci U S A. 1989 Jan; 86(1): 129–132.


Yes, more gaps and transitions to fill. You really don't get it do you. But at least you're making a good attempt at at a response which is more than I can say for this guy:

https://www.reddit.com/r/THUNDERDOME_DEBATE/comments/6auvhc/does_the_professor_of_darcrapolgy_think_selective/

Interestingly enough https://www.amazon.com/gp/aw/d/1259188124/ and https://www.amazon.com/gp/aw/d/1464126119/ref=mp_s_a_1_1?ie=UTF8&qid=1520567419&sr=8-1&pi=AC_SX236_SY340_FMwebp_QL65&keywords=lehninger+principles+of+biochemistry+7th+edition&dpPl=1&dpID=51S8Bgm9FmL&ref=plSrch disagree with your text. And, seeing as I have more experience with both these texts, and poisons and toxins fall into what I do professionally, we're going to have to agree to disagree.

I kept them (the engineering ones at least). At great personal cost though.

Every now and then I hit one or two of the key upper level books specially within heat transfer, fluids, thermo, and process design. I even had to break out a math book once or twice. But, I work a design job where such references will pop up. If I was running a process or running a plant I doubt I would have had the need.

Also, your text books aren't worth NEARLY what you think they are... new editions pop up all the times, and even a year or two will render their value on the market to "pretty low" despite the content of course being super useful.

Anyways... I kept mine, and my wife made me build a large built in bookshelf to house them and then put me on a book in/book out diet because I have so many god damn books. I actually have two degrees (Biochemistry too) and I had all my biochem books. Even though I have ZERO need for them, getting rid of MOST of them was REALLY hard, despite the information not even being accurate anymore (degree was in 2003).

Now my Lehninger's Biochemistry book (https://www.amazon.com/Lehninger-Principles-Biochemistry-David-Nelson/dp/1464126119/) and Albert's The Cell (https://www.amazon.com/Molecular-Biology-Sixth-Bruce-Alberts/dp/0815344325/) are used as "rug flatteners" for our area rugs because they are so heavy.

She's a vet... and one of the first things she did was part with all her vet books except for a few.

If you want actual science behind it I highly recommend reading an actual book students are taught from: Leninnger Principles of Biochemistry by) (this are clean, non-affiliate links). You should be able to borrow it from the library, any edition should do.

Specifically the chapter on human metabolism, and pay attention to what is a set-point.

This is all not new, it has been known for ages. Dr Fungs books started popularizing this knowledge recently, thumbs up to him for that