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14 Gauge Fuse Holder ATC/ATO, SIM&NAT 10 Packs in-Line Automotive Blade Fuse Holder with 50PCS Standard Car Fuses, 1A 2A 3A / 4A 5A 7.5A 10A 15A 20A 30A Automotive Replacement Fuses

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1 Reddit comment about 14 Gauge Fuse Holder ATC/ATO, SIM&NAT 10 Packs in-Line Automotive Blade Fuse Holder with 50PCS Standard Car Fuses, 1A 2A 3A / 4A 5A 7.5A 10A 15A 20A 30A Automotive Replacement Fuses:

u/marshray · 2 pointsr/AskElectronics

>What's the danger of doing something like this?

Building on a pre-made unit with a low voltage output takes away so many worries. So assuming that the ATX PSU stays in good working order..

The biggest danger comes from the fact that the unit will happily pump 100 amps into the right kind of short. As the other commenter said, there may be some short-circuit protection, but there must be some range of loads into which it will deliver that maximum power. Whatever your project was supposed to be, it is now inside-out toaster oven.

Keep it powered off whenever you're not there watching it.

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>And is there a way to protect from shorting two different power lines?

Assuming you don't actually need hundreds of amps, I would:
Disconnect all but one of each (e.g., red and yellow) of the power wires. Doesn't have to be permanent, just take the end out of the ATX connector, insulate it, and tie it back neatly. Keep at least as many ground lines.
Put an inline ("pigtail") automotive ATC/ATO fuse holder in each of the supply lines you want to use. Something like (no affiliate) 14 Gauge Fuse Holder ATC/ATO, 10 Packs in-Line Automotive Blade Fuse Holder with 50PCS Standard Car Fuses

There are all kinds of thermistors, PTC switches, and other options for resettable circuit breakers worth looking into, but you'll never regret having an assortment of fuses handy.

Now that you've got MOSFETs working in switching configuration, you might look into enhancing your supply with adjustable current limiting.

- Marsh